InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eef1e1

Summary

InnateDB Protein

IDBP-146131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eef1e1

Protein Name

eukaryotic translation elongation factor 1 epsilon 1

Synonyms

1110003A02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001757

InnateDB Gene

IDBG-146129 (Eef1e1)

Protein Structure

UniProt Annotation

Function

Positive modulator of ATM response to DNA damage. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15680327}. Nucleus {ECO:0000269PubMed:15680327}. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes at S phase and following DNA damage.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006412	translation
GO:0008285	negative regulation of cell proliferation
GO:0009790	embryo development
GO:0043065	positive regulation of apoptotic process
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:2001235	positive regulation of apoptotic signaling pathway