InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr6

Summary

InnateDB Protein

IDBP-146159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr6

Protein Name

G protein-coupled receptor 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057323

InnateDB Gene

IDBG-146157 (Gpr6)

Protein Structure

UniProt Annotation

Function

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305PubMed:17284443}; Multi-pass membrane protein {ECO:0000305PubMed:17284443}. Note=Highly expressed and localized along the cytoplasmic membrane as well as in a perinuclear compartment.

Disease Associations

Tissue Specificity

Mainly expressed in the brain. Selectively expressed in striatopallidal neurons in the striatum. {ECO:0000269PubMed:17284443, ECO:0000269PubMed:17934457}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2155249

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000723 G protein-coupled receptor 3/6/12 orphan
IPR001151 G protein-coupled receptor 6
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00644
PR00649

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6YNI2