InnateDB Protein
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IDBP-146200.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mapre3
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Protein Name
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microtubule-associated protein, RP/EB family, member 3
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Synonyms
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AI790651; EB2; EB3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031058
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InnateDB Gene
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IDBG-146198 (Mapre3)
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Protein Structure
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Function |
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the microtubule network. Detected at the plus end of microtubules (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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|
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Molecular Function |
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Biological Process |
GO:0007067
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mitotic nuclear division
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GO:0045737
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positive regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:1903033
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positive regulation of microtubule plus-end binding
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Cellular Component |
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PDB ID |
MGI:2140967
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InterPro |
IPR001715
Calponin homology domain
IPR004953
EB1, C-terminal
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PFAM |
PF00307
PF03271
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PRINTS |
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PIRSF |
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SMART |
SM00033
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PER3
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PhosphoSite |
PhosphoSite-Q6PER3
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TrEMBL |
Q2UZW7
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UniProt Splice Variant |
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Entrez Gene |
100732
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UniGene |
Mm.471154
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RefSeq |
NP_579928
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MGI ID |
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MGI Symbol |
Mapre3
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OMIM |
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CCDS |
CCDS19163
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HPRD |
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IMGT |
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EMBL |
AC109606
AC109611
AF468005
BC057918
U51204
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GenPept |
AAA96321
AAH57918
AAQ05030
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