Version 5.4
Mus musculus Protein: Tmem214
Summary
InnateDB Protein IDBP-146236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem214
Protein Name transmembrane protein 214
Synonyms 1110039B18Rik; 4921530J21Rik; AI841294; AU018742; C76280;
Species Mus musculus
Ensembl Protein ENSMUSP00000037484
InnateDB Gene IDBG-146234 (Tmem214)
Protein Structure
UniProt Annotation
Function Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006915 apoptotic process
GO:0008150 biological_process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005881 cytoplasmic microtubule
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1916046
InterPro IPR019308 Protein of unknown function DUF2359, TMEM214
PFAM PF10151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BM55
PhosphoSite PhosphoSite-Q8BM55
TrEMBL
UniProt Splice Variant
Entrez Gene 68796
UniGene Mm.205169
RefSeq NP_653108
MGI ID
MGI Symbol Tmem214
OMIM
CCDS CCDS19164
HPRD
IMGT
EMBL AK034883 AK143078 AK166510 BC022142 BC022602 BC026651 BC027046 BC029150
GenPept AAH22142 AAH22602 AAH26651 AAH27046 AAH29150 BAC28866 BAE25265 BAE38819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca