InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mitd1

Summary

InnateDB Protein

IDBP-146411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mitd1

Protein Name

MIT, microtubule interacting and transport, domain containing 1

Synonyms

1500032H18Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027257

InnateDB Gene

IDBG-146409 (Mitd1)

Protein Structure

UniProt Annotation

Function

Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Midbody {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0000920	cytokinetic cell separation
GO:0006810	transport
GO:0032091	negative regulation of protein binding
GO:1902409	mitotic cytokinetic cell separation

Cellular Component

GO:0019898	extrinsic component of membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome