InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dusp26

Summary

InnateDB Protein

IDBP-146467.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp26

Protein Name

dual specificity phosphatase 26 (putative)

Synonyms

2310043K02Rik; Skrp3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046794

InnateDB Gene

IDBG-146465 (Dusp26)

Protein Structure

UniProt Annotation

Function

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain and skeletal muscle. In the brain it is expressed ubiquitously except in the hippocampus. {ECO:0000269PubMed:16581800, ECO:0000269PubMed:17001450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0002039	p53 binding
GO:0004647	phosphoserine phosphatase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045785	positive regulation of cell adhesion
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902310	positive regulation of peptidyl-serine dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1914209

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020405 Atypical dual specificity phosphatase, subfamily A
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PR01909
PR01908

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt