InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfrkb

Summary

InnateDB Protein

IDBP-146983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfrkb

Protein Name

nuclear factor related to kappa B binding protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083341

InnateDB Gene

IDBG-146981 (Nfrkb)

Protein Structure

UniProt Annotation

Function

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000250}.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process