Version 5.4
Mus musculus Protein: Gif
Summary
InnateDB Protein IDBP-147043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gif
Protein Name gastric intrinsic factor
Synonyms AV073125;
Species Mus musculus
Ensembl Protein ENSMUSP00000025585
InnateDB Gene IDBG-147041 (Gif)
Protein Structure
UniProt Annotation
Function Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Gastric mucosa.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004784 superoxide dismutase activity
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0006824 cobalt ion transport
GO:0009235 cobalamin metabolic process
GO:0015889 cobalamin transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005902 microvillus
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID MGI:1202394
InterPro IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
IPR019831 Manganese/iron superoxide dismutase, N-terminal
PFAM PF01122
PF00081
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52787
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14603
UniGene Mm.456
RefSeq NP_032144
MGI ID
MGI Symbol Gif
OMIM
CCDS CCDS29609
HPRD
IMGT
EMBL AK078933 BC118519 CH466534 L24191 L24192
GenPept AAA37881 AAA37882 AAI18520 BAC37468 EDL41439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca