Version 5.4
Mus musculus Protein: Ankrd28
Summary
InnateDB Protein IDBP-147052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ankrd28
Protein Name ankyrin repeat domain 28
Synonyms AI465466; AI604979; E430019N21Rik; mKIAA0379;
Species Mus musculus
Ensembl Protein ENSMUSP00000014640
InnateDB Gene IDBG-147050 (Ankrd28)
Protein Structure
UniProt Annotation
Function Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed (at protein level). {ECO:0000269PubMed:16564677}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:2145661
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q505D1
PhosphoSite PhosphoSite-Q505D1
TrEMBL Q5DU34
UniProt Splice Variant
Entrez Gene 105522
UniGene Mm.407940
RefSeq NP_001019775
MGI ID
MGI Symbol Ankrd28
OMIM
CCDS CCDS36858
HPRD
IMGT
EMBL AK220336 BC051456 BC094609
GenPept AAH51456 AAH94609 BAD90403

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca