Version 5.4
Mus musculus Protein: Aadac
Summary
InnateDB Protein IDBP-147363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aadac
Protein Name arylacetamide deacetylase (esterase)
Synonyms 5033417E09Rik; Aada; AI265437;
Species Mus musculus
Ensembl Protein ENSMUSP00000029325
InnateDB Gene IDBG-147361 (Aadac)
Protein Structure
UniProt Annotation
Function Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000250, ECO:0000269PubMed:19654421, ECO:0000269PubMed:22207054}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:19654421}; Single-pass type II membrane protein {ECO:0000269PubMed:19654421}. Microsome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highest levels in liver with lower levels in jejunum and kidney. {ECO:0000269PubMed:19654421, ECO:0000269PubMed:22207054}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0017171 serine hydrolase activity
GO:0019213 deacetylase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0010898 positive regulation of triglyceride catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915008
InterPro IPR013094 Alpha/beta hydrolase fold-3
IPR017157 Arylacetamide deacetylase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF07859
PRINTS
PIRSF PIRSF037251
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99PG0
PhosphoSite PhosphoSite-Q99PG0
TrEMBL
UniProt Splice Variant
Entrez Gene 67758
UniGene Mm.24547
RefSeq NP_075872
MGI ID
MGI Symbol Aadac
OMIM
CCDS CCDS17375
HPRD
IMGT
EMBL AF306788 BC019999 BC054823
GenPept AAG60035 AAH19999 AAH54823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca