InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirt5

Summary

InnateDB Protein

IDBP-147403.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt5

Protein Name

sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)

Synonyms

0610012J09Rik; 1500032M05Rik; AV001953;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071048

InnateDB Gene

IDBG-147401 (Sirt5)

Protein Structure

UniProt Annotation

Function

NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox. {ECO:0000269PubMed:19410549, ECO:0000269PubMed:21908771, ECO:0000269PubMed:22076378, ECO:0000269PubMed:23085393, ECO:0000269PubMed:23806337}.

Subcellular Localization

Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.

Disease Associations

Tissue Specificity

Detected in brain, liver, heart, kidney, lung, thymus, spleen, skeletal muscle, intestine, pancreas and testis (at protein level). {ECO:0000269PubMed:19410549}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

Biological Process

GO:0006476	protein deacetylation
GO:0036047	peptidyl-lysine demalonylation
GO:0036048	protein desuccinylation
GO:0036049	peptidyl-lysine desuccinylation
GO:2000378	negative regulation of reactive oxygen species metabolic process