Mus musculus Protein: Sirt5
Summary
InnateDB Protein IDBP-147403.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sirt5
Protein Name sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
Synonyms 0610012J09Rik; 1500032M05Rik; AV001953;
Species Mus musculus
Ensembl Protein ENSMUSP00000071048
InnateDB Gene IDBG-147401 (Sirt5)
Protein Structure
UniProt Annotation
Function NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox. {ECO:0000269PubMed:19410549, ECO:0000269PubMed:21908771, ECO:0000269PubMed:22076378, ECO:0000269PubMed:23085393, ECO:0000269PubMed:23806337}.
Subcellular Localization Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.
Disease Associations
Tissue Specificity Detected in brain, liver, heart, kidney, lung, thymus, spleen, skeletal muscle, intestine, pancreas and testis (at protein level). {ECO:0000269PubMed:19410549}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006476 protein deacetylation
GO:0036047 peptidyl-lysine demalonylation
GO:0036048 protein desuccinylation
GO:0036049 peptidyl-lysine desuccinylation
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1915596
InterPro IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF02146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K2C6
PhosphoSite PhosphoSite-
TrEMBL Q5M8R0
UniProt Splice Variant
Entrez Gene 68346
UniGene
RefSeq NP_849179
MGI ID
MGI Symbol Sirt5
OMIM
CCDS CCDS26478
HPRD
IMGT
EMBL BC031770 BC087898
GenPept AAH31770 AAH87898