InnateDB Protein
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IDBP-147403.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sirt5
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Protein Name
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sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
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Synonyms
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0610012J09Rik; 1500032M05Rik; AV001953;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000071048
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InnateDB Gene
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IDBG-147401 (Sirt5)
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Protein Structure
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Function |
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox. {ECO:0000269PubMed:19410549, ECO:0000269PubMed:21908771, ECO:0000269PubMed:22076378, ECO:0000269PubMed:23085393, ECO:0000269PubMed:23806337}.
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Subcellular Localization |
Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.
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Disease Associations |
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Tissue Specificity |
Detected in brain, liver, heart, kidney, lung, thymus, spleen, skeletal muscle, intestine, pancreas and testis (at protein level). {ECO:0000269PubMed:19410549}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
75 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915596
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InterPro |
IPR003000
Sirtuin family
IPR026590
Sirtuin family, catalytic core domain
IPR029035
DHS-like NAD/FAD-binding domain
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PFAM |
PF02146
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K2C6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q5M8R0
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UniProt Splice Variant |
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Entrez Gene |
68346
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UniGene |
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RefSeq |
NP_849179
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MGI ID |
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MGI Symbol |
Sirt5
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OMIM |
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CCDS |
CCDS26478
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HPRD |
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IMGT |
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EMBL |
BC031770
BC087898
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GenPept |
AAH31770
AAH87898
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