InnateDB Protein
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IDBP-147920.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Prrxl1
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Protein Name
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paired related homeobox protein-like 1
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Synonyms
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Drg11; Drgx;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000064107
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InnateDB Gene
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IDBG-147918 (Prrxl1)
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Protein Structure
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Function |
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. {ECO:0000269PubMed:11498051}.
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Subcellular Localization |
Nucleus {ECO:0000250UniProtKB:P54821, ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000255PROSITE- ProRule:PRU00138}.
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Disease Associations |
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Tissue Specificity |
Expressed in the dorsal horn of the spinal cord and dorsal root ganglia. Isoform 1 is higher expressed than isoform 2 both in the dorsal root ganglia and in the spinal cord. Isoform 2 is exclusively localized in neurons primarily involved in the processing of the pain somatosensory modality. {ECO:0000269PubMed:11498051, ECO:0000269PubMed:19598127}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2148204
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BYH0
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PhosphoSite |
PhosphoSite-Q8BYH0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
107751
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UniGene |
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RefSeq |
NP_001001796
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MGI ID |
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MGI Symbol |
Prrxl1
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OMIM |
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CCDS |
CCDS26922
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HPRD |
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IMGT |
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EMBL |
AK039633
AY116506
BC132613
BC145917
EU670677
EU670678
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GenPept |
AAI32614
AAI45918
AAM49062
ACD45984
ACD45985
BAC30405
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