Version 5.4
Mus musculus Protein: Glyat
Summary
InnateDB Protein IDBP-148067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glyat
Protein Name glycine-N-acyltransferase
Synonyms A330009E03Rik; ACGNAT; AI195249; AI315345; CAT; GAT;
Species Mus musculus
Ensembl Protein ENSMUSP00000043308
InnateDB Gene IDBG-148065 (Glyat)
Protein Structure
UniProt Annotation
Function Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0047961 glycine N-acyltransferase activity
GO:0047962 glycine N-benzoyltransferase activity
Biological Process
GO:0006544 glycine metabolic process
GO:0008150 biological_process
GO:0009636 response to toxic substance
GO:0032787 monocarboxylic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2147502
InterPro IPR013652 Glycine N-acyltransferase, C-terminal
IPR015938 Glycine N-acyltransferase, N-terminal
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF08444
PF06021
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91XE0
PhosphoSite PhosphoSite-Q91XE0
TrEMBL
UniProt Splice Variant
Entrez Gene 107146
UniGene Mm.39974
RefSeq NP_666047
MGI ID
MGI Symbol Glyat
OMIM
CCDS CCDS29633
HPRD
IMGT
EMBL AK039262 AK143803 AK143901 BC010799 BC015294 BC024434
GenPept AAH10799 AAH15294 AAH24434 BAC30297 BAE25544 BAE25590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca