InnateDB Protein
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IDBP-148461.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tmem30b
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Protein Name
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transmembrane protein 30B
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000037476
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InnateDB Gene
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IDBG-148459 (Tmem30b)
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Protein Structure
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Function |
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane (By similarity). {ECO:0000250, ECO:0000305}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0070863
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positive regulation of protein exit from endoplasmic reticulum
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Cellular Component |
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PDB ID |
MGI:2442082
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InterPro |
IPR005045
Protein of unknown function DUF284, transmembrane eukaryotic
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PFAM |
PF03381
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PRINTS |
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PIRSF |
PIRSF015840
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BHG3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q0VEI2
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UniProt Splice Variant |
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Entrez Gene |
238257
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UniGene |
Mm.251196
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RefSeq |
NP_848830
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MGI ID |
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MGI Symbol |
Tmem30b
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OMIM |
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CCDS |
CCDS25975
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HPRD |
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IMGT |
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EMBL |
AK030302
AK033580
AK037246
AK169014
BC119224
BC119226
CH466526
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GenPept |
AAI19225
AAI19227
BAC26887
BAC28372
BAC29774
BAE40811
EDL36505
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