InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ramp3

Summary

InnateDB Protein

IDBP-148616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ramp3

Protein Name

receptor (calcitonin) activity modifying protein 3

Synonyms

AI850306;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047518

InnateDB Gene

IDBG-148614 (Ramp3)

Protein Structure

UniProt Annotation

Function

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269PubMed:10854696, ECO:0000269PubMed:23674134}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269PubMed:23674134}. Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in the testis, embryonic and adult brain and in kidney. {ECO:0000269PubMed:10777702, ECO:0000269PubMed:10854696}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0031623	receptor internalization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0071392	cellular response to estradiol stimulus
GO:0072659	protein localization to plasma membrane
GO:0086103	G-protein coupled receptor signaling pathway involved in heart process
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex