InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift172

Summary

InnateDB Protein

IDBP-148720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift172

Protein Name

intraflagellar transport 172 homolog (Chlamydomonas)

Synonyms

4930553F24Rik; avc1; Slb; wim;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049335

InnateDB Gene

IDBG-148718 (Ift172)

Protein Structure

UniProt Annotation

Function

Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway. {ECO:0000269PubMed:14603322, ECO:0000269PubMed:16061793}.

Subcellular Localization

Cell projection, cilium {ECO:0000305}.

Disease Associations

Tissue Specificity

Co-localizes with RABL2/RABL2A in the midpiece of elongated spermatids within the testis (at protein level). {ECO:0000269PubMed:23055941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001841	neural tube formation
GO:0001843	neural tube closure
GO:0001947	heart looping
GO:0007219	Notch signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007368	determination of left/right symmetry
GO:0007420	brain development
GO:0007507	heart development
GO:0008544	epidermis development
GO:0008589	regulation of smoothened signaling pathway
GO:0009953	dorsal/ventral pattern formation
GO:0016485	protein processing
GO:0021522	spinal cord motor neuron differentiation
GO:0021915	neural tube development
GO:0031122	cytoplasmic microtubule organization
GO:0042384	cilium assembly
GO:0045880	positive regulation of smoothened signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060021	palate development
GO:0060173	limb development
GO:0060271	cilium morphogenesis
GO:0060348	bone development
GO:0061525	hindgut development
GO:0070986	left/right axis specification

Cellular Component

GO:0005929	cilium
GO:0030992	intraciliary transport particle B
GO:0031514	motile cilium
GO:0036064	ciliary basal body
GO:0097225	sperm midpiece
GO:0097228	sperm principal piece