InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Igfbp3

Summary

InnateDB Protein

IDBP-148895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igfbp3

Protein Name

insulin-like growth factor binding protein 3

Synonyms

AI649005; IGFBP-3; IGgfbp3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020702

InnateDB Gene

IDBG-148893 (Igfbp3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008160	protein tyrosine phosphatase activator activity
GO:0031994	insulin-like growth factor I binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001649	osteoblast differentiation
GO:0001933	negative regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0010906	regulation of glucose metabolic process
GO:0014912	negative regulation of smooth muscle cell migration
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044342	type B pancreatic cell proliferation
GO:0045663	positive regulation of myoblast differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96438

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR012211 Insulin-like growth factor binding protein 3
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata

PFAM

PF00086
PF00219

PRINTS

PR01979
PR01976

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt