InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpmt

Summary

InnateDB Protein

IDBP-148939.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpmt

Protein Name

thiopurine methyltransferase

Synonyms

AW106912;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021806

InnateDB Gene

IDBG-148937 (Tpmt)

Protein Structure

UniProt Annotation

Function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008119	thiopurine S-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity

Biological Process

GO:0032259	methylation
GO:0033574	response to testosterone

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98812

InterPro

IPR008854 TPMT family
IPR025835 Thiopurine S-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05724

PRINTS

PIRSF

PIRSF023956

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O55060

PhosphoSite

PhosphoSite-O55060

TrEMBL

D3Z217

UniProt Splice Variant

Entrez Gene

22017

UniGene

Mm.10169

RefSeq

NP_058065

MGI ID

3BGI

MGI Symbol

Tpmt

OMIM

CCDS

CCDS26488

HPRD

IMGT

EMBL

AC096628 AF037043 AF037044 AF046887 AF104825 AF104826 AF104827 AF104828 AF104829 AF104830 AF104831 AF104832 AH009424 BC021598

GenPept

AAC25919 AAD02092 AAD02093 AAF06075 AAF74424 AAH21598