InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OXTR

Summary

InnateDB Protein

IDBP-14903.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXTR

Protein Name

oxytocin receptor

Synonyms

OT-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000324270

InnateDB Gene

IDBG-14899 (OXTR)

Protein Structure

UniProt Annotation

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004990	oxytocin receptor activity
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0001967	suckling behavior
GO:0001975	response to amphetamine
GO:0006936	muscle contraction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0007613	memory
GO:0010701	positive regulation of norepinephrine secretion
GO:0014070	response to organic cyclic compound
GO:0021537	telencephalon development
GO:0030431	sleep
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0034059	response to anoxia
GO:0034097	response to cytokine
GO:0035176	social behavior
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0042711	maternal behavior
GO:0042713	sperm ejaculation
GO:0042755	eating behavior
GO:0043434	response to peptide hormone
GO:0044058	regulation of digestive system process
GO:0045777	positive regulation of blood pressure
GO:0048545	response to steroid hormone
GO:0048565	digestive tract development
GO:0051965	positive regulation of synapse assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060137	maternal process involved in parturition
GO:0060206	estrous cycle phase
GO:0060406	positive regulation of penile erection
GO:0060455	negative regulation of gastric acid secretion
GO:0070371	ERK1 and ERK2 cascade
GO:0070474	positive regulation of uterine smooth muscle contraction

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005913	cell-cell adherens junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001817 Vasopressin receptor
IPR002062 Oxytocin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10320
PF10323

PRINTS

PR00237
PR00896
PR00665

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30559