InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glud1

Summary

InnateDB Protein

IDBP-149408.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glud1

Protein Name

glutamate dehydrogenase 1

Synonyms

AI118167; Gdh-X; Glud; Gludl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022322

InnateDB Gene

IDBG-149406 (Glud1)

Protein Structure

UniProt Annotation

Function

Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. {ECO:0000269PubMed:23663782}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004352	glutamate dehydrogenase (NAD+) activity
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006541	glutamine metabolic process
GO:0007616	long-term memory
GO:0010044	response to aluminum ion
GO:0032024	positive regulation of insulin secretion
GO:0055114	oxidation-reduction process
GO:0072350	tricarboxylic acid metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:95753

InterPro

IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain

PFAM

PF00208
PF02812

PRINTS

PR00082

PIRSF

SMART

SM00839

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt