InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gars

Summary

InnateDB Protein

IDBP-149463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gars

Protein Name

glycyl-tRNA synthetase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003572

InnateDB Gene

IDBG-149461 (Gars)

Protein Structure

UniProt Annotation

Function

Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004820	glycine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006426	glycyl-tRNA aminoacylation
GO:0015966	diadenosine tetraphosphate biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0030141	secretory granule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2449057

InterPro

IPR000738 WHEP-TRS
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR002315 Glycyl-tRNA synthetase, alpha2 dimer
IPR004154 Anticodon-binding
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR009068 S15/NS1, RNA-binding

PFAM

PF00458
PF00587
PF03129

PRINTS

PR01043

PIRSF

SMART

SM00991

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt