InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tle4

Summary

InnateDB Protein

IDBP-149466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tle4

Protein Name

transducin-like enhancer of split 4, homolog of Drosophila E(spl)

Synonyms

5730411M05Rik; AA792082; Bce-1; Bce1; ESTM13; ESTM14; Grg4; X83332; X83333;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057527

InnateDB Gene

IDBG-149464 (Tle4)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. {ECO:0000269PubMed:12050133, ECO:0000269PubMed:21317240}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0016055	Wnt signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:104633

InterPro

IPR001680 WD40 repeat
IPR005617 Groucho/TLE, N-terminal Q-rich domain
IPR009146 Groucho/transducin-like enhancer
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF03920

PRINTS

PR01850

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt