InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgpp1

Summary

InnateDB Protein

IDBP-149471.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgpp1

Protein Name

sphingosine-1-phosphate phosphatase 1

Synonyms

AI463453; SPP; SPP1; Spph1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021450

InnateDB Gene

IDBG-149469 (Sgpp1)

Protein Structure

UniProt Annotation

Function

Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in liver and kidney. {ECO:0000269PubMed:10859351}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0042392	sphingosine-1-phosphate phosphatase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006668	sphinganine-1-phosphate metabolic process
GO:0006670	sphingosine metabolic process
GO:0016311	dephosphorylation
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway