InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adipoq

Summary

InnateDB Protein

IDBP-149535.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adipoq

Protein Name

adiponectin, C1Q and collagen domain containing

Synonyms

30kDa; Acdc; Acrp30; adipo; apM1; APN; GBP28;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023593

InnateDB Gene

IDBG-149533 (Adipoq)

Protein Structure

UniProt Annotation

Function

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269PubMed:11479627, ECO:0000269PubMed:11479628, ECO:0000269PubMed:12840063, ECO:0000269PubMed:15734737, ECO:0000269PubMed:15760892}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Synthesized exclusively by adipocytes and secreted into plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	10 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0033691	sialic acid binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0006006	glucose metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0007584	response to nutrient
GO:0007623	circadian rhythm
GO:0009744	response to sucrose stimulus
GO:0009749	response to glucose
GO:0009967	positive regulation of signal transduction
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875	positive regulation of cholesterol efflux
GO:0010906	regulation of glucose metabolic process
GO:0014823	response to activity
GO:0014912	negative regulation of smooth muscle cell migration
GO:0019395	fatty acid oxidation
GO:0030336	negative regulation of cell migration
GO:0030853	negative regulation of granulocyte differentiation
GO:0031667	response to nutrient levels
GO:0031953	negative regulation of protein autophosphorylation
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032757	positive regulation of interleukin-8 production
GO:0032869	cellular response to insulin stimulus
GO:0033034	positive regulation of myeloid cell apoptotic process
GO:0033211	adiponectin-activated signaling pathway
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0034383	low-density lipoprotein particle clearance
GO:0034612	response to tumor necrosis factor
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045599	negative regulation of fat cell differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045721	negative regulation of gluconeogenesis
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045923	positive regulation of fatty acid metabolic process
GO:0046326	positive regulation of glucose import
GO:0046888	negative regulation of hormone secretion
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050765	negative regulation of phagocytosis
GO:0050805	negative regulation of synaptic transmission
GO:0050873	brown fat cell differentiation
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0051899	membrane depolarization
GO:0060081	membrane hyperpolarization
GO:0070208	protein heterotrimerization
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070543	response to linoleic acid
GO:0070994	detection of oxidative stress
GO:0071320	cellular response to cAMP
GO:0071639	positive regulation of monocyte chemotactic protein-1 production
GO:0071872	cellular response to epinephrine stimulus
GO:0072659	protein localization to plasma membrane
GO:0090317	negative regulation of intracellular protein transport
GO:1900121	negative regulation of receptor binding
GO:2000279	negative regulation of DNA biosynthetic process
GO:2000467	positive regulation of glycogen (starch) synthase activity
GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development
GO:2000481	positive regulation of cAMP-dependent protein kinase activity
GO:2000534	positive regulation of renal albumin absorption
GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000590	negative regulation of metanephric mesenchymal cell migration

Cellular Component

GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0009986	cell surface
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery