InnateDB Protein
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IDBP-149547.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sncg
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Protein Name
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synuclein, gamma
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Synonyms
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C79089; persyn;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023826
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InnateDB Gene
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IDBG-149545 (Sncg)
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Protein Structure
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Function |
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Expressed predominantly in the cell bodies and axons of primary sensory neurons, sympathetic neurons and motoneurons.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1298397
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InterPro |
IPR001058
Synuclein
IPR002462
Gamma-synuclein
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PFAM |
PF01387
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PRINTS |
PR01211
PR01214
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0F7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q5GQ64
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UniProt Splice Variant |
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Entrez Gene |
20618
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UniGene |
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RefSeq |
NP_035560
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MGI ID |
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MGI Symbol |
Sncg
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OMIM |
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CCDS |
CCDS26937
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HPRD |
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IMGT |
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EMBL |
AF017255
AF099984
AF099985
AF099986
AJ786826
AK141509
BC028508
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GenPept |
AAC98893
AAD19899
AAH28508
BAE24706
CAH17958
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