InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gckr

Summary

InnateDB Protein

IDBP-149700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gckr

Protein Name

glucokinase regulatory protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072084

InnateDB Gene

IDBG-149698 (Gckr)

Protein Structure

UniProt Annotation

Function

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030246	carbohydrate binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0009750	response to fructose
GO:0033132	negative regulation of glucokinase activity
GO:0033133	positive regulation of glucokinase activity
GO:0043086	negative regulation of catalytic activity
GO:0046415	urate metabolic process
GO:0070328	triglyceride homeostasis