InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agpat2

Summary

InnateDB Protein

IDBP-149802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agpat2

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)

Synonyms

2510002J07Rik; AV000834; BSCL; BSCL1; LPAAB; LPAAT-beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028286

InnateDB Gene

IDBG-149798 (Agpat2)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269PubMed:15367102}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in the liver, at intermediate levels in the kidney, gut, heart and skeletal muscles. Undetectable in brain and spleen. {ECO:0000269PubMed:15367102}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008544	epidermis development
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process