InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptx3

Summary

InnateDB Protein

IDBP-149889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptx3

Protein Name

pentraxin related gene

Synonyms

AI607804; TSG-14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029421

InnateDB Gene

IDBG-149887 (Ptx3)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. {ECO:0000269PubMed:9407058}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0001872	(1->3)-beta-D-glucan binding
GO:0046790	virion binding

Biological Process

GO:0001878	response to yeast
GO:0008228	opsonization
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0046597	negative regulation of viral entry into host cell
GO:0050766	positive regulation of phagocytosis
GO:1903016	negative regulation of exo-alpha-sialidase activity
GO:1903019	negative regulation of glycoprotein metabolic process