Version 5.4
Mus musculus Protein: Tpp2
Summary
InnateDB Protein IDBP-149900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpp2
Protein Name tripeptidyl peptidase II
Synonyms TPP-2; TppII;
Species Mus musculus
Ensembl Protein ENSMUSP00000085244
InnateDB Gene IDBG-149896 (Tpp2)
Protein Structure
UniProt Annotation
Function Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Stimulates adipogenesis. {ECO:0000250, ECO:0000269PubMed:17932511}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19747897}. Nucleus {ECO:0000269PubMed:19747897}. Note=Translocates to the nucleus in responce to gamma-irradiation.
Disease Associations
Tissue Specificity Expressed in the brain, skeletal muscle, gonadal and mesenteric white adipose tissue and brown adipose tissues. {ECO:0000269PubMed:17932511}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008240 tripeptidyl-peptidase activity
GO:0042277 peptide binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:102724
InterPro IPR000209 Peptidase S8/S53 domain
IPR015500 Peptidase S8, subtilisin-related
IPR022229 Peptidase S8A, tripeptidyl peptidase II
PFAM PF00082
PF12580
PRINTS PR00723
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64514
PhosphoSite PhosphoSite-Q64514
TrEMBL
UniProt Splice Variant
Entrez Gene 22019
UniGene
RefSeq NP_033444
MGI ID
MGI Symbol Tpp2
OMIM
CCDS CCDS14926
HPRD
IMGT
EMBL BC058239 X81323
GenPept AAH58239 CAA57103

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca