InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arc

Summary

InnateDB Protein

IDBP-149969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arc

Protein Name

activity regulated cytoskeletal-associated protein

Synonyms

Arc3.1; arg3.1; C86064; mArc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023268

InnateDB Gene

IDBG-149967 (Arc)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. {ECO:0000250, ECO:0000269PubMed:17088210, ECO:0000269PubMed:17088213}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250UniProtKB:Q63053}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:12493697}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Enriched on the plasma membrane (By similarity). Associated with the sperm tail. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain and testis. {ECO:0000269PubMed:12493697}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007492	endoderm development
GO:0007612	learning
GO:0009952	anterior/posterior pattern specification
GO:0016477	cell migration
GO:0022604	regulation of cell morphogenesis
GO:0048168	regulation of neuronal synaptic plasticity

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane