Version 5.4
Mus musculus Protein: Fam120a
Summary
InnateDB Protein IDBP-150076.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam120a
Protein Name family with sequence similarity 120, member A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000053877
InnateDB Gene IDBG-150074 (Fam120a)
Protein Structure
UniProt Annotation
Function Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm. {ECO:0000250, ECO:0000269PubMed:18413649}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to plasma membrane upon ultraviolet exposure. {ECO:0000250}.
Disease Associations
Tissue Specificity Present in Purkinje cells in the cerebellum, and in cortical neurons (at protein level). {ECO:0000269PubMed:18413649}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2446163
InterPro IPR029060 PIN domain-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6A0A9
PhosphoSite PhosphoSite-Q6A0A9
TrEMBL Q7TMZ0
UniProt Splice Variant
Entrez Gene 218236
UniGene Mm.477812
RefSeq NP_001028440
MGI ID
MGI Symbol Fam120a
OMIM
CCDS CCDS49259
HPRD
IMGT
EMBL AK035074 AK172909 BC010304 BC042582 BC054362 BC158134
GenPept AAH10304 AAH42582 AAH54362 AAI58135 BAD32187 BAE20495

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca