Version 5.4
Mus musculus Protein: Ly6d
Summary
InnateDB Protein IDBP-150230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ly6d
Protein Name lymphocyte antigen 6 complex, locus D
Synonyms Ly-61; Ly61; Thb;
Species Mus musculus
Ensembl Protein ENSMUSP00000047419
InnateDB Gene IDBG-150228 (Ly6d)
Protein Structure
UniProt Annotation
Function May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. {ECO:0000269PubMed:19833765}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Lymphoid cells lacking Ly6d, called ALP (all- lymphoid progenitor), retain full lymphoid potential and early thymic seeding activity, whereas cells containing Ly6d, called BLP (B-cell-biased lymphoid progenitor), up-regulate the B-cell specifying factors Ebf1 and Pax5 and behave essentially as B-cell progenitors (at protein level). Thymocytes and B-cells. {ECO:0000269PubMed:19833765}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030098 lymphocyte differentiation
GO:0035634 response to stilbenoid
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:96881
InterPro IPR001526 CD59 antigen
IPR016054 Ly-6 antigen / uPA receptor -like
PFAM PF00021
PRINTS
PIRSF
SMART SM00134
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35459
PhosphoSite PhosphoSite-P35459
TrEMBL
UniProt Splice Variant
Entrez Gene 17068
UniGene
RefSeq NP_034872
MGI ID
MGI Symbol Ly6d
OMIM
CCDS CCDS27531
HPRD
IMGT
EMBL BC025135 L40419 X63782
GenPept AAA79249 AAH25135 CAA45317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca