InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF17

Summary

InnateDB Protein

IDBP-15044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF17

Protein Name

tumor necrosis factor receptor superfamily, member 17

Synonyms

BCM; BCMA; CD269; TNFRSF13A;

Species

Homo sapiens

Ensembl Protein

ENSP00000053243

InnateDB Gene

IDBG-15042 (TNFRSF17)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269PubMed:10801128, ECO:0000269PubMed:10903733, ECO:0000269PubMed:10973284}.

Subcellular Localization

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.

Disease Associations

Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Tissue Specificity

Expressed in mature B-cells, but not in T- cells or monocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity

Biological Process

GO:0002376	immune system process
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0033209	tumor necrosis factor-mediated signaling pathway