Version 5.4
Mus musculus Protein: Adamts13
Summary
InnateDB Protein IDBP-150459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adamts13
Protein Name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099955
InnateDB Gene IDBG-150457 (Adamts13)
Protein Structure
UniProt Annotation
Function Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. {ECO:0000269PubMed:15869605}.
Subcellular Localization Secreted {ECO:0000269PubMed:15136581}. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats. {ECO:0000250}.
Disease Associations
Tissue Specificity Plasma. Expression is consistently high in liver, medium in lung and spleen, low in skeletal muscle and undetectable in heart, brain, kidney and testis. {ECO:0000269PubMed:15136581, ECO:0000269PubMed:15869605}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0009636 response to toxic substance
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
GO:0043171 peptide catabolic process
GO:0070670 response to interleukin-4
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:2685556
InterPro IPR000859 CUB domain
IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR006586 ADAM, cysteine-rich
IPR013273 Peptidase M12B, ADAM-TS
PFAM PF00431
PF00090
PF01421
PF08516
PRINTS PR01857
PIRSF
SMART SM00042
SM00209
SM00608
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q769J6
PhosphoSite PhosphoSite-Q769J6
TrEMBL
UniProt Splice Variant
Entrez Gene 279028
UniGene Mm.330084
RefSeq NP_001001322
MGI ID
MGI Symbol Adamts13
OMIM
CCDS CCDS15820
HPRD
IMGT
EMBL AB071302 AB095445 AB112362 AL773563 AL845266
GenPept BAC55159 BAD04062 BAD18090 CAM23711 CAM24664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca