InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbtb1

Summary

InnateDB Protein

IDBP-150579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbtb1

Protein Name

zinc finger and BTB domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041955

InnateDB Gene

IDBG-150577 (Zbtb1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Represses cAMP- responsive element (CRE)-mediated transcriptional activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of early lymphoid progenitors to develop into T-cell lineage. {ECO:0000269PubMed:22201126, ECO:0000269PubMed:22753936}.

Subcellular Localization

Nucleus. Nucleus, nucleoplasm {ECO:0000250}. Note=Localized in dot-like structures in the nucleus. Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed strongly in thymus and spleen, less in lymph nodes and peripheral blood mononuclear cells (PBMCs) and weakly in bone marrow. Strongly expressed in immature, but weakly in mature bone marrow-lymphocyte B. {ECO:0000269PubMed:22753936}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002711	positive regulation of T cell mediated immunity
GO:0030183	B cell differentiation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045087	innate immune response
GO:0045582	positive regulation of T cell differentiation
GO:0048538	thymus development
GO:0051260	protein homooligomerization
GO:2000176	positive regulation of pro-T cell differentiation