InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem8c

Summary

InnateDB Protein

IDBP-150605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem8c

Protein Name

transmembrane protein 8C

Synonyms

1110002H13Rik; AI131587;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009358

InnateDB Gene

IDBG-150603 (Tmem8c)

Protein Structure

UniProt Annotation

Function

Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction. {ECO:0000269PubMed:23868259}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23868259}; Multi-pass membrane protein {ECO:0000269PubMed:23868259}. Note=Localizes on the cell surface of myoblasts during fusion and is down-regulated thereafter.

Disease Associations

Tissue Specificity

Specifically expressed in skeletal muscle during embryogenesis and adult muscle regeneration. {ECO:0000269PubMed:23868259}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007517	muscle organ development
GO:0007520	myoblast fusion
GO:0045026	plasma membrane fusion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1913389

InterPro

IPR021910 Protein of unknown function DUF3522

PFAM

PF12036

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D1N4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

66139

UniGene

Mm.330087

RefSeq

NP_079652

MGI ID

MGI Symbol

Tmem8c

OMIM

CCDS

CCDS15823

HPRD

IMGT

EMBL

AK003298 AL845266 BC062145

GenPept

AAH62145 BAB22699 CAM24661