InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grid1

Summary

InnateDB Protein

IDBP-150626.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grid1

Protein Name

glutamate receptor, ionotropic, delta 1

Synonyms

GluD1; GluRdelta1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044009

InnateDB Gene

IDBG-150624 (Grid1)

Protein Structure

UniProt Annotation

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Equally in forebrain and cerebellum. {ECO:0000269PubMed:1372507}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity

Biological Process

GO:0006810	transport
GO:0034220	ion transmembrane transport
GO:0035176	social behavior
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0008328	ionotropic glutamate receptor complex
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95812

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt