InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd99l2

Summary

InnateDB Protein

IDBP-150701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd99l2

Protein Name

CD99 antigen-like 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078944

InnateDB Gene

IDBG-150697 (Cd99l2)

Protein Structure

UniProt Annotation

Function

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation. {ECO:0000269PubMed:17344467, ECO:0000269PubMed:18163232, ECO:0000269PubMed:20479283}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000269PubMed:17344467}. Note=Concentrated at cell-cell contacts in cultured endothelial cells.

Disease Associations

Tissue Specificity

Highly expressed in the nervous system, including brain, dentate nucleus of hippocampus, granular and Purkinje cells of cerebellum, brain stem nucleus and choroid plexus. Expressed in peripheral blood T- and B-cells and neutrophils (at protein level). Almost undetectable in bone marrow-derived neutrophils (at protein level). Also expressed in thymocytes (at protein level) with higher expression in cortical thymocytes than in medullary thymocytes. Expressed at high levels in testis (mostly in germ cells and Sertoli cells) and ovary (mostly in granulosa cells). Expressed in lung, heart, kidney and liver (at protein level); however, expression in heart, kidney and liver seems restricted to endothelial cells (at protein level). Highly expressed in endothelial cells and to a lower level in vascular smooth muscle cells (at protein level). Low expression in spleen. {ECO:0000269PubMed:12706889, ECO:0000269PubMed:17344467, ECO:0000269PubMed:18163232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.