InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clcn7

Summary

InnateDB Protein

IDBP-150777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcn7

Protein Name

chloride channel 7

Synonyms

AA409691; AW538136; ClC-7; D17Wsu51e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035964

InnateDB Gene

IDBG-150775 (Clcn7)

Protein Structure

UniProt Annotation

Function

Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. {ECO:0000269PubMed:16525474, ECO:0000269PubMed:19661288}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:16525474}; Multi-pass membrane protein {ECO:0000269PubMed:16525474}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006821	chloride transport
GO:0009268	response to pH
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport