InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Egfr

Summary

InnateDB Protein

IDBP-151198.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Egfr

Protein Name

epidermal growth factor receptor

Synonyms

9030024J15Rik; AI552599; Erbb; Errb1; Errp; wa-2; wa2; Wa5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099948

InnateDB Gene

IDBG-151194 (Egfr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 344 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	344 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005006	epidermal growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001892	embryonic placenta development
GO:0001942	hair follicle development
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007435	salivary gland morphogenesis
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021795	cerebral cortex cell migration
GO:0042127	regulation of cell proliferation
GO:0046777	protein autophosphorylation
GO:0048546	digestive tract morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0060571	morphogenesis of an epithelial fold

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0030139	endocytic vesicle
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:95294

InterPro

IPR000494 EGF receptor, L domain
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF01030
PF00757

PRINTS

PIRSF

SMART

SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite