Version 5.4
Mus musculus Protein: Brd3
Summary
InnateDB Protein IDBP-151262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brd3
Protein Name bromodomain containing 3
Synonyms 2410084F24Rik; AW060456; Fsrg2; ORFX; RINGL3;
Species Mus musculus
Ensembl Protein ENSMUSP00000028282
InnateDB Gene IDBG-151260 (Brd3)
Protein Structure
UniProt Annotation
Function Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription of the CCND1 gene (By similarity). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21536911}. Note=Detected on chromatin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1914632
InterPro IPR001487 Bromodomain
PFAM PF00439
PRINTS PR00503
PIRSF
SMART SM00297
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K2F0
PhosphoSite PhosphoSite-Q8K2F0
TrEMBL Q3TUI3
UniProt Splice Variant
Entrez Gene 67382
UniGene Mm.415648
RefSeq NP_075825
MGI ID 2L5E
MGI Symbol Brd3
OMIM
CCDS CCDS15828
HPRD
IMGT
EMBL AF269193 AK037435 AK076472 AK159827 AK160752 AK167573 AL772282 BC031536 CH466542
GenPept AAF78072 AAH31536 BAC29806 BAC36359 BAE35406 BAE35988 BAE39636 EDL08369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca