InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nsdhl

Summary

InnateDB Protein

IDBP-151448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nsdhl

Protein Name

NAD(P) dependent steroid dehydrogenase-like

Synonyms

AI747449; Bpa; H105E3; Str; XAP104;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033715

InnateDB Gene

IDBG-151446 (Nsdhl)

Protein Structure

UniProt Annotation

Function

Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Note=Trafficking through the Golgi is necessary for ER membrane localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047012	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0050662	coenzyme binding

Biological Process

GO:0001942	hair follicle development
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0007224	smoothened signaling pathway
GO:0008203	cholesterol metabolic process
GO:0009058	biosynthetic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1099438

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR008030 NmrA-like
IPR013120 Male sterility, NAD-binding

PFAM

PF01370
PF01073
PF02719
PF04321
PF05368
PF07993

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R1J0

PhosphoSite