Version 5.4
Mus musculus Protein: 5730469M10Rik
Summary
InnateDB Protein IDBP-151489.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 5730469M10Rik
Protein Name RIKEN cDNA 5730469M10 gene
Synonyms 5730469M10Rik; AU040822; Pamm;
Species Mus musculus
Ensembl Protein ENSMUSP00000022317
InnateDB Gene IDBG-151487 (5730469M10Rik)
Protein Structure
UniProt Annotation
Function Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in kidney, liver, skin, and brain. {ECO:0000269PubMed:19951071}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0045670 regulation of osteoclast differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1917814
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
PFAM PF00578
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CYH2
PhosphoSite PhosphoSite-Q9CYH2
TrEMBL D3Z398
UniProt Splice Variant
Entrez Gene 70564
UniGene Mm.464147
RefSeq NP_081740
MGI ID
MGI Symbol Fam213a
OMIM
CCDS CCDS26957
HPRD
IMGT
EMBL AC154597 AK017688 BC056635
GenPept AAH56635 BAB30875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca