InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc46a2

Summary

InnateDB Protein

IDBP-151826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc46a2

Protein Name

solute carrier family 46, member 2

Synonyms

5430429N04Rik; Ly110; Tscot; TSO-1C12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030081

InnateDB Gene

IDBG-151824 (Slc46a2)

Protein Structure

UniProt Annotation

Function

May act as a transporter. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed on cortical epithelial cells in the thymus. Mainly expressed in the thymic cortex and is highly enriched in SCID thymus. Also expressed in lymph nodes, heart, fetal liver, brain, spleen, intestine and kidney, but not in adult liver, skin, skeletal muscle and lung. {ECO:0000269PubMed:10706709, ECO:0000269PubMed:10978518}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005215	transporter activity

Biological Process

GO:0043029	T cell homeostasis
GO:0045580	regulation of T cell differentiation
GO:0048538	thymus development
GO:0055085	transmembrane transport
GO:0070233	negative regulation of T cell apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1353616

InterPro

IPR001958 Tetracycline resistance protein, TetA/multidrug resistance protein MdtG
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter

PFAM

PF07690

PRINTS

PR01035

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CA03