InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sftpd

Summary

InnateDB Protein

IDBP-151873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sftpd

Protein Name

surfactant associated protein D

Synonyms

AI573415; Sftp4; SP-D;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076383

InnateDB Gene

IDBG-151871 (Sftpd)

Protein Structure

UniProt Annotation

Function

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

Subcellular Localization

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007585	respiratory gaseous exchange
GO:0043129	surfactant homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0048286	lung alveolus development

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109515

InterPro

IPR001304 C-type lectin
IPR008160 Collagen triple helix repeat
IPR015097 Lung surfactant protein D coiled-coil trimerisation
IPR016187 C-type lectin fold

PFAM

PF00059
PF01391
PF09006

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50404