InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mup4

Summary

InnateDB Protein

IDBP-151896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mup4

Protein Name

major urinary protein 4

Synonyms

Mup-4; Mup1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075356

InnateDB Gene

IDBG-151894 (Mup4)

Protein Structure

UniProt Annotation

Function

Binds pheromones, likely to displace pheromones complexed to urinary MUPs and transport them to the vomeronasal organ (VNO) where they associate with their neuronal receptor(s). MUP4 is highly specific for the male mouse pheromone 2-sec-butyl- 4,5-dihydrothiazole (SBT). {ECO:0000269PubMed:12192080, ECO:0000269PubMed:20509168}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in lacrimal gland, parotid gland, sublingual gland, nasal mucus, and vomeronasal organ. {ECO:0000269PubMed:3600653}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005009	insulin-activated receptor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005550	pheromone binding
GO:0036094	small molecule binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006810	transport
GO:0008286	insulin receptor signaling pathway
GO:0009060	aerobic respiration
GO:0010628	positive regulation of gene expression
GO:0010888	negative regulation of lipid storage
GO:0010907	positive regulation of glucose metabolic process
GO:0031649	heat generation
GO:0042593	glucose homeostasis
GO:0045475	locomotor rhythm
GO:0045721	negative regulation of gluconeogenesis
GO:0045834	positive regulation of lipid metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051055	negative regulation of lipid biosynthetic process
GO:0051897	positive regulation of protein kinase B signaling
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070584	mitochondrion morphogenesis
GO:0071396	cellular response to lipid

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:97236

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002345 Lipocalin
IPR002447 Beta-lactoglobulin
IPR002448 Odour-binding protein
IPR002450 von Ebner\'s gland protein/ Bos/Can allergen
IPR002968 Alpha-1-microglobulin
IPR002971 Major urinary protein
IPR002972 Prostaglandin D synthase
IPR011038 Calycin-like

PFAM

PF00061
PF08212

PRINTS