InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gja1

Summary

InnateDB Protein

IDBP-152174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gja1

Protein Name

gap junction protein, alpha 1

Synonyms

AU042049; AW546267; Cnx43; connexin43; Cx43; Cx43alpha1; Gja-1; Npm1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064536

InnateDB Gene

IDBG-152172 (Gja1)

Protein Structure

UniProt Annotation

Function

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. {ECO:0000269PubMed:22549838}.Connexin 43 is possibly the ATP-induced pore of mouse macrophages. {ECO:0000269PubMed:22549838}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Disease Associations

Tissue Specificity

Expressed in heart, non-sensory epithelial cells, and in fibrocytes of the spiral ligament and the spiral limbus. Expressed in bladder smooth muscle cells (at protein level). {ECO:0000269PubMed:11741837, ECO:0000269PubMed:2178193, ECO:0000269PubMed:22549838}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005243	gap junction channel activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019904	protein domain specific binding
GO:0030165	PDZ domain binding
GO:0048487	beta-tubulin binding
GO:0071253	connexin binding
GO:0097110	scaffold protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001947	heart looping
GO:0002070	epithelial cell maturation
GO:0002088	lens development in camera-type eye
GO:0002544	chronic inflammatory response
GO:0003104	positive regulation of glomerular filtration
GO:0003158	endothelium development
GO:0003294	atrial ventricular junction remodeling
GO:0003347	epicardial cell to mesenchymal cell transition
GO:0006915	apoptotic process
GO:0007154	cell communication
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0007507	heart development
GO:0007512	adult heart development
GO:0008016	regulation of heart contraction
GO:0008285	negative regulation of cell proliferation
GO:0009268	response to pH
GO:0009749	response to glucose
GO:0010232	vascular transport
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010643	cell communication by chemical coupling
GO:0010644	cell communication by electrical coupling
GO:0010652	positive regulation of cell communication by chemical coupling
GO:0015867	ATP transport
GO:0030500	regulation of bone mineralization
GO:0032024	positive regulation of insulin secretion
GO:0034405	response to fluid shear stress
GO:0035050	embryonic heart tube development
GO:0042733	embryonic digit morphogenesis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403	skeletal muscle tissue regeneration
GO:0043434	response to peptide hormone
GO:0045216	cell-cell junction organization
GO:0045732	positive regulation of protein catabolic process
GO:0045844	positive regulation of striated muscle tissue development
GO:0045907	positive regulation of vasoconstriction
GO:0045909	positive regulation of vasodilation
GO:0046850	regulation of bone remodeling
GO:0048514	blood vessel morphogenesis
GO:0048812	neuron projection morphogenesis
GO:0051259	protein oligomerization
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060156	milk ejection
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060312	regulation of blood vessel remodeling
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061045	negative regulation of wound healing
GO:0061337	cardiac conduction
GO:0071260	cellular response to mechanical stimulus
GO:0090162	establishment of epithelial cell polarity
GO:2000279	negative regulation of DNA biosynthetic process
GO:2000810	regulation of tight junction assembly
GO:2000987	positive regulation of behavioral fear response

Cellular Component

GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005764	lysosome
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005916	fascia adherens
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0043292	contractile fiber
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95713

InterPro

IPR000500 Connexin
IPR002261 Gap junction alpha-1 protein (Cx43)
IPR013092 Connexin, N-terminal
IPR013124 Gap junction alpha-1 protein (Cx43), C-terminal
IPR019570 Gap junction protein, cysteine-rich domain

PFAM

PF00029
PF03508
PF10582

PRINTS

PR00206
PR01132

PIRSF

SMART

SM00037
SM01089

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt