InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptger2

Summary

InnateDB Protein

IDBP-152675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptger2

Protein Name

prostaglandin E receptor 2 (subtype EP2)

Synonyms

EP2; Ptgerep2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038483

InnateDB Gene

IDBG-152673 (Ptger2)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0042127	regulation of cell proliferation
GO:0071380	cellular response to prostaglandin E stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:97794

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001105 Thromboxane receptor
IPR001923 Prostanoid EP2 receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00429
PR00581
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62053