InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atoh1

Summary

InnateDB Protein

IDBP-152862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atoh1

Protein Name

atonal homolog 1 (Drosophila)

Synonyms

bHLHa14; Hath1; MATH-1; Math1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098903

InnateDB Gene

IDBG-152860 (Atoh1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. {ECO:0000269PubMed:10648228}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:10648228}.

Disease Associations

Tissue Specificity

Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0007411	axon guidance
GO:0007420	brain development
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0042667	auditory receptor cell fate specification
GO:0042668	auditory receptor cell fate determination
GO:0043066	negative regulation of apoptotic process
GO:0045609	positive regulation of auditory receptor cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:2000982	positive regulation of inner ear receptor cell differentiation