Version 5.4
Mus musculus Protein: Gtf3c4
Summary
InnateDB Protein IDBP-152968.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf3c4
Protein Name general transcription factor IIIC, polypeptide 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042265
InnateDB Gene IDBG-152966 (Gtf3c4)
Protein Structure
UniProt Annotation
Function Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008150 biological_process
GO:0016573 histone acetylation
Cellular Component
GO:0000127 transcription factor TFIIIC complex
Protein Structure and Domains
PDB ID MGI:2138937
InterPro IPR017986 WD40-repeat-containing domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMQ2
PhosphoSite PhosphoSite-Q8BMQ2
TrEMBL E9Q2B0
UniProt Splice Variant
Entrez Gene 269252
UniGene Mm.26043
RefSeq NP_766565
MGI ID
MGI Symbol Gtf3c4
OMIM
CCDS CCDS15847
HPRD
IMGT
EMBL AK030351 AK047698 AL732526 BC061476 BC117919 BC117920 CH466542
GenPept AAH61476 AAI17920 AAI17921 BAC26916 BAC33130 CAM21459 EDL08398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca